In addition to mouse models, we focus strongly on translational research in large animals
While hundreds of nanomedicine studies are produced every year, very few formulations are clinically approved. This is partly due to an undue reliance on murine studies, which suffer from limited value in accurately predicting translational efficacy in humans. To combat this experimental hindrance, our lab established a translational nanomedicine program with large animal models, ranging from rabbits to swine to non-human primates. It involves scaling up production and testing while in the preclinical phase, which provides a unique framework in preparing for clinical studies. In combination with access to clinical scanners through the BioMedical Engineering and Imaging Institute, we have the unique privilege to study our therapies and probes in large animal models while performing imaging studies using some of the most advanced multimodality systems available..